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A drug decades ago Used to treat high blood pressure has Been Shown to Improve learning and memory in mouse models of Alzheimer’s disease years, According To a new study by Researchers at the National Institute on Aging (NIA), part of the National Institutes of Health. That the study found the drug, Diaz oxide, ACTED on nerve cells in the mouse brain in Ways That Slowed the Development of the neurodegenerative disorder. The Findings Appear in the Nov. 15, 2010, print edition of the Journal of Alzheimer’s Disease years.

Mark P. Mattson, Ph.D., chief of NIA’s Laboratory of Neurosciences in Baltimore, Directed the research, in Collaboration with colleagues at Keokuk University College of Veterinary Medicine, Seoul, South Korea, and the Indiana University School of Medicine, Indianapolis.

That Mattson’s team found Diaz oxide stabilized nerve cells in the brain and preventive biological cascade in the mice That Can result in the destruction of these cells. The drug Also Improved blood flow in the brain and Prevented the Harmful Accumulation of two proteins, beta-amyloidal and taut, Which Are hallmarks of Alzheimer’s years. Widely used in the 1970s and ’80s to treat Patients with Severe hypertension, Diaz oxide is Currently Used to treat hypoglycemia, or low blood sugar.

“These intriguing new avenues open Findings of basic research That May Increase Our Understanding of how modulating the electrical activity of nerve cells May slow the damage” wrought by Alzheimer’s disease pathology years, “NIA Director Richard J. Said Hades, M.D. “More research Will Be Needed before We Can determine whether this May Be A Potential Therapy for Alzheimer’s.”

NIA scientists Studied two groups of Alzheimer mice years, one Given Diaz oxide inn drinking water and one given a placebo. After eight months, the Diaz oxide group outperforms the placebo group on a standard test of learning and memory. The brain tissue of the Treated group Reichmann Fewer deposits of amyloidal and taut proteins, less damage “due to oxidative stress, and Better blood flow, Diaz oxide us all Indications That May Have Harmful suppressed cellular Some of the changes file associated with Alzheimer’s disease.